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Supercooled storage of red blood cells slows down the metabolic storage lesion | Scientific Reports
Acetaminophen toxicity can result from either a single toxic dose or from repeated cumulative dosages resulting in methemoglobinemia, hepatotoxicosis, facial and paw edema, depression, weakness, tachypnea, dyspnea, cyanosis, icterus, vomiting, hypothermia, hepatic necrosis, and death in severe cases [112,113]
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Regardless, mechanistically, caloric restriction appears to reduce damage accumulation by decreasing reactive oxygen species, lowering oxidative DNA and protein damage, improving DNA repair (Heydari et al., 2007